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Research theme 01

Aerosol Science & Environmental Health

Fabrice's Ph.D. work at the University of Miami investigated electronic-cigarette aerosols as complex mixtures of particles, gases and metals whose properties evolve with device configuration and operating conditions.

Research focus

The theme treats an everyday consumer device as a small chemical plant: a heated system that generates a dynamic aerosol whose particle number, size, chemistry and biological effect all depend on how it is operated.

Because both users and bystanders are exposed, the work measures firsthand and secondhand emissions — connecting engineering measurements to human exposure rather than stopping at the device.

Impact message Engineering exposure science — connecting device operation → emission characteristics → respiratory exposure → biological response.

In the record

Contributions represented in the publication record.

2022

Primary and secondhand metal emissions

A Chemical Research in Toxicology study examined metal contents in primary and secondhand aerosols, helping quantify an exposure pathway not captured by nicotine-only discussions.

2024

Oxidation state matters

Metal-speciation work examined the chemical states of emitted metals. Toxicity cannot always be inferred from total concentration alone; chemical form influences biological behavior and hazard.

2025

A single puff is highly dynamic

Transient-emission research used fast measurements to capture particle and gas behavior over the timescale of an individual puff — particle sizes spanning roughly 5–1000 nm with a strong ultrafine component.

2025

Exposure conditions influence cellular outcomes

A toxicity study exposed human alveolar epithelial A549 cells at an air–liquid interface, showing device- and dose-dependent reductions in viability and disruptions to epithelial barrier integrity.